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Experiments in hairless albino mice suggest that concurrent publicity to tretinoin may perhaps enhance the tumorigenic likely of carcinogenic doses of UVB and UVA light-weight from the solar simulator. This influence continues to be verified in a later on review in pigmented mice, and dim pigmentation did not conquer the enhancement of photocarcinogenesis by 0.
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The mutagenic prospective of tretinoin was evaluated within the Ames assay and inside the in vivo mouse micronucleus assay, each of which had been detrimental.
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